Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 15/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 13/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.51 |
| ▸ | SETDB1 | Q15047 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817688 | 0.87 | F2 (0.43) | F2PRSS1PRSS2PRSS3SETDB1 | |
| SCHEMBL7817408 | 0.87 | F2 (0.43) | F2PRSS1PRSS2PRSS3SETDB1 | |
| SCHEMBL7819771 | 0.86 | F2 (0.41) | F2PRSS1PRSS2PRSS3SETDB1 | |
| SCHEMBL7824021 | 0.83 | F2 (0.39) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7819680 | 0.83 | NR2F2 (0.39) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7817562 | 0.83 | F2 (0.44) | F2PRSS1PRSS2PRSS3SETDB1 | |
| SCHEMBL7817160 | 0.82 | F2 (0.41) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7811676 | 0.81 | F2 (0.52) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7825524 | 0.81 | F2 (0.60) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7818083 | 0.81 | F2 (0.41) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |