Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817160 | 0.83 | F2 (0.41) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7818083 | 0.82 | F2 (0.41) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7824021 | 0.81 | F2 (0.39) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7819625 | 0.81 | F2 (0.41) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7811676 | 0.81 | F2 (0.52) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7809378 | 0.80 | F2 (0.44) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7825524 | 0.80 | F2 (0.60) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7819771 | 0.80 | F2 (0.41) | F2PRSS1PRSS2PRSS3KDM4E | |
| SCHEMBL7819935 | 0.80 | F2 (0.46) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7818207 | 0.79 | F2 (0.47) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |