Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 17/20 | 0.62 |
| ▸ | CDK2 | P24941 | 17/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 12/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819672 | 1.00 | CCNE1 (0.62) | CCNE1CDK2CCNE2PIM1MAPK8 | |
| SCHEMBL7820117 | 0.90 | CCNE1 (0.74) | CCNE1CDK2CCNE2 | |
| SCHEMBL7820122 | 0.90 | CCNE1 (0.74) | CCNE1CDK2CCNE2 | |
| SCHEMBL7830227 | 0.89 | CCNE1 (0.66) | CCNE1CDK2CCNE2MAPK8 | |
| SCHEMBL7830230 | 0.89 | CCNE1 (0.66) | CCNE1CDK2CCNE2MAPK8 | |
| SCHEMBL27556911 | 0.83 | CCNE1 (0.53) | CCNE1CDK2CCNE2MAPK8 | |
| SCHEMBL27556909 | 0.82 | CCNE1 (0.52) | CCNE1CDK2CCNE2PIM1MAPK8 | |
| SCHEMBL7820012 | 0.81 | CCNE1 (0.61) | CCNE1CDK2CCNE2MAPK8 | |
| SCHEMBL7819760 | 0.81 | CCNE1 (0.61) | CCNE1CDK2CCNE2MAPK8 | |
| SCHEMBL7819758 | 0.81 | CCNE1 (0.61) | CCNE1CDK2CCNE2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | claimed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | claimed |
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6307056-B1 | INHIBIT OR MODULATE PROTEIN KINASES, IN PARTICULAR JNK PROTEIN KINASES. | HOFFMAN-LA ROCHE INC. | 2001-10-23 | — | — | US | disclosed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |