Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1270290 | 0.77 | EPHX2 (0.51) | EPHX2BRD4CREBBPKDM1AMAOB | |
| SCHEMBL19228314 | 0.77 | EPHX2 (0.51) | EPHX2BRD4CREBBPKDM1AMAOB | |
| SCHEMBL29596637 | 0.77 | EPHX2 (0.51) | EPHX2BRD4CREBBPKDM1AMAOB | |
| SCHEMBL7427232 | 0.77 | EPHX2 (0.51) | EPHX2BRD4CREBBPKDM1AMAOB | |
| SCHEMBL7819751 | 0.75 | EPHX2 (0.46) | EPHX2BRD4CREBBPKDM1AMAOB | |
| SCHEMBL20344426 | 0.70 | EPHX2 (0.58) | EPHX2BRD4CREBBPKDM1AMAOB | |
| SCHEMBL24981627 | 0.68 | EPHX2 (0.53) | EPHX2BRD4CREBBPKDM1AMAOB | |
| SCHEMBL28450919 | 0.68 | EPHX2 (0.66) | EPHX2KDM1AMAOBMAPK10GAA | |
| SCHEMBL6814816 | 0.68 | KDM1A (0.50) | EPHX2KDM1AMAOBNFKB1NFKB2 | |
| SCHEMBL12242248 | 0.68 | KDM1A (0.74) | EPHX2KDM1AMAOBKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730581-B1 | 3-ACYLAMINOBENZAZEPINES | MERCK & CO INC (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-0730581-A4 | 3-ACYLAMINOBENZAZEPINES | MERCK & CO INC (US) | 1997-02-05 | — | — | EP | disclosed |
| EP-0730581-A1 | 3-ACYLAMINOBENZAZEPINES | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014671-A1 | 3-ACYLAMINOBENZAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |