Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 17/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 14/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.44 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824393 | 0.85 | MAPT (0.46) | F2 | |
| SCHEMBL7811676 | 0.82 | F2 (0.52) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7820059 | 0.81 | F2 (0.51) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7824021 | 0.81 | F2 (0.39) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7817408 | 0.80 | F2 (0.43) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7825524 | 0.79 | F2 (0.60) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7818083 | 0.79 | F2 (0.41) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7819771 | 0.79 | F2 (0.41) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7817160 | 0.79 | F2 (0.41) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7825334 | 0.79 | F2 (0.50) | F2PRSS1PRSS2PRSS3MASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900207-B1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |