Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | F12 | P00748 | 1/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084038 | 1.00 | ESR1 (0.48) | ESR1BLMRECQLTSHRF2 | |
| SCHEMBL9248612 | 0.83 | ESR1 (0.48) | ESR1BLMRECQLTSHRF2 | |
| SCHEMBL3902058 | 0.82 | ESR1 (0.56) | ESR1BLMRECQLTSHRF2 | |
| SCHEMBL11844374 | 0.82 | ESR1 (0.56) | ESR1BLMRECQLTSHRF2 | |
| SCHEMBL1035354 | 0.82 | ESR1 (0.56) | ESR1BLMRECQLTSHRF2 | |
| SCHEMBL6255440 | 0.81 | ESR1 (0.46) | ESR1BLMRECQLTSHRF2 | |
| SCHEMBL3149795 | 0.81 | ESR1 (0.46) | ESR1BLMRECQLTSHRF2 | |
| SCHEMBL23278527 | 0.79 | ESR1 (0.61) | ESR1TSHRMAPTL3MBTL1CES2 | |
| Hydrochloric Acid SCHEMBL7317199 | 0.79 | BLM (0.48) | ESR1BLMRECQLTSHRF2 | |
| Hydrochloric Acid SCHEMBL7317191 | 0.79 | BLM (0.48) | ESR1BLMRECQLTSHRF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102754-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007997-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS α1A AGONISTS | ABBOTT LABORATORIES (US) | 2000-02-17 | — | — | WO | disclosed |