Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.59 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.58 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.58 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897673 | 0.87 | ALK (0.79) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL1755853 | 0.87 | ALK (0.77) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL20004413 | 0.87 | ALK (0.76) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL1756021 | 0.86 | ALK (0.70) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL10283130 | 0.86 | ALK (0.64) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL1755985 | 0.83 | ALK (0.77) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL7814670 | 0.83 | ALK (0.59) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL1755841 | 0.82 | ALK (0.78) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL1755998 | 0.82 | ALK (0.76) | ALKEML4SRPK2SRPK1KDR | |
| SCHEMBL7813252 | 0.81 | ALK (0.57) | ALKEML4SRPK2SRPK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |