Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218883 | 0.76 | PDPK1 (0.45) | PDPK1HSP90AB1MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL7814496 | 0.72 | FGFR1 (0.41) | PDPK1HSP90AB1MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL7820094 | 0.70 | CHEK1 (0.49) | MAPK1MAP2K4MAPKAPK2MAPK6FGFR1 | |
| SCHEMBL7820618 | 0.69 | ESR1 (0.41) | PDPK1HSP90AB1MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL13891857 | 0.65 | ESR1 (0.39) | LMNAESR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5215395 | 0.64 | SMN1; SMN2 (0.39) | MAPK1LMNAESR1CYP1A2CYP3A4 | |
| SCHEMBL15214863 | 0.63 | PDPK1 (0.44) | PDPK1HSP90AB1MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL10361565 | 0.63 | GRM5 (0.46) | PDPK1HSP90AB1MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL10445993 | 0.62 | ESR1 (0.65) | LMNAESR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7919067 | 0.62 | ESR1 (0.53) | MAPK1LMNAESR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102753-A2 | PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007996-A2 | PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS | CHIRON CORPORATION (US) | 2000-02-17 | — | — | WO | disclosed |