Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.76 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782193 | 1.00 | HSP90AA1 (0.76) | HSP90AA1AKR1B10AKR1B1MAOBPTGS2 | |
| Hydrochloric Acid SCHEMBL11197008 | 0.99 | HSP90AA1 (0.78) | HSP90AA1AKR1B10AKR1B1MAOBPTGS2 | |
| Hydrochloric Acid SCHEMBL11197002 | 0.99 | HSP90AA1 (0.78) | HSP90AA1AKR1B10AKR1B1MAOBPTGS2 | |
| SCHEMBL780338 | 0.88 | HSP90AA1 (0.74) | HSP90AA1MAOBHDAC3HDAC4HDAC1 | |
| SCHEMBL780339 | 0.88 | HSP90AA1 (0.74) | HSP90AA1MAOBHDAC3HDAC4HDAC1 | |
| SCHEMBL782305 | 0.87 | HSP90AA1 (0.97) | HSP90AA1MAOBMAPTALDH1A1KMT2A | |
| SCHEMBL782304 | 0.87 | HSP90AA1 (0.97) | HSP90AA1MAOBMAPTALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL11197407 | 0.86 | HSP90AA1 (0.76) | HSP90AA1HDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL11121413 | 0.86 | HSP90AA1 (0.76) | HSP90AA1MAOBHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL11197403 | 0.86 | HSP90AA1 (0.76) | HSP90AA1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250041255-A1 | COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE SKIN DISEASES | YALE UNIVERSITY | 2025-02-06 | — | — | US | disclosed |
| US-10881656-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2021-01-05 | — | — | US | disclosed |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
| US-9604958-B2 | HIF inhibitors and use thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2015-01-22 | — | — | US | disclosed |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2012-03-22 | — | — | US | disclosed |
| WO-2010068794-A2 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2010-06-17 | — | — | WO | disclosed |
| US-4400380-A | HERBES VIRUS; TOPICAL | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10881656-B2 | HIF inhibitors and use thereof | HIF1AN, HIF1A, EGLN3 | HSP90AA1 110/4885AKR1B10 1475/4885AKR1B1 533/4885 |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | HSP90AA1 110/4885AKR1B10 1475/4885AKR1B1 533/4885 |
| US-20150023868-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | HSP90AA1 110/4885AKR1B10 1475/4885AKR1B1 533/4885 |
| US-20250041255-A1 | COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE SKIN DISEASES | HIF1AN, HIF1A, SSB | HSP90AA1 918/4885AKR1B10 4227/4885AKR1B1 4041/4885 |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | HSP90AA1 110/4885AKR1B10 1475/4885AKR1B1 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.