Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.83 |
| ▸ | MAPT | P10636 | 3/20 | 0.83 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.75 |
| ▸ | NPC1 | O15118 | 4/20 | 0.75 |
| ▸ | RAB9A | P51151 | 4/20 | 0.75 |
| ▸ | RAC1 | P63000 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ACACA | Q13085 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321436 | 0.88 | RAC1 (0.84) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL3321880 | 0.87 | KDM4E (0.80) | KDM4EMAPTMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL3318470 | 0.87 | RAC1 (0.85) | KDM4EMAPTMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL3318463 | 0.86 | KDM4E (0.78) | KDM4EMAPTMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL3318461 | 0.86 | KDM4E (0.78) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL3324961 | 0.86 | KDM4E (1.00) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL13334166 | 0.85 | RAC1 (1.00) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL3322189 | 0.85 | KDM4E (0.70) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL3320461 | 0.85 | RAC1 (1.00) | KDM4EMAPTMEN1KMT2ANPC1 | |
| SCHEMBL3320163 | 0.84 | KDM4E (0.76) | KDM4EMAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888346-B1 | CORALYNE ANALOGS AS TOPOISOMERASE INHIBITORS | UNIV RUTGERS (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-0888346-A1 | CORALYNE ANALOGS AS TOPOISOMERASE INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997029106-A1 | CORALYNE ANALOGS AS TOPOISOMERASE INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1997-08-14 | — | — | WO | disclosed |