Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ASPH | Q12797 | 2/20 | 0.59 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.59 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.59 |
| ▸ | VNN1 | O95497 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851862 | 0.90 | MCHR1 (0.59) | MCHR1KDM4EASPHKDM8RIOX2 | |
| Hydrochloric Acid SCHEMBL7835428 | 0.83 | KDM4E (0.52) | MCHR1KDM4EASPHKDM8RIOX2 | |
| SCHEMBL7835443 | 0.82 | MCHR1 (0.52) | MCHR1KDM4EASPHKDM8RIOX2 | |
| SCHEMBL14734428 | 0.81 | KDM4E (0.54) | MCHR1KDM4EASPHKDM8RIOX2 | |
| SCHEMBL7832332 | 0.80 | MCHR1 (0.56) | MCHR1KDM4EVNN1MAPTMEN1 | |
| SCHEMBL21805201 | 0.80 | HTT (0.54) | MCHR1VNN1POLBMAPTHTT | |
| SCHEMBL1715769 | 0.79 | NPC1 (0.66) | KDM4EASPHKDM8RIOX2MAPT | |
| SCHEMBL24157190 | 0.78 | KDM4E (0.65) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL3730790 | 0.78 | KDM4E (0.76) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL30253210 | 0.78 | KDM4E (0.65) | KDM4EASPHKDM8RIOX2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784622-B1 | NAPHTHYRIDINONE DERIVATIVES | KNOLL GMBH (DE) | 2001-11-21 | — | — | EP | disclosed |
| US-5854257-A | Naphthyridinone derivatives | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |