Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 7/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824075 | 0.80 | EPHB3 (0.44) | EPHB3NPC1RAB9AGAAMAPT | |
| SCHEMBL7824773 | 0.80 | EPHB3 (0.50) | EPHB3NPC1RAB9AGAAMAPT | |
| SCHEMBL7824798 | 0.79 | GAA (0.49) | EPHB3DRD2DRD3NPC1RAB9A | |
| SCHEMBL18879064 | 0.73 | EPHB3 (0.50) | EPHB3DRD3NPC1RAB9AGAA | |
| SCHEMBL30009953 | 0.71 | EPHB3 (0.63) | EPHB3NPC1RAB9AGAAMAPT | |
| SCHEMBL21436533 | 0.71 | EPHB3 (0.63) | EPHB3NPC1RAB9AGAAMAPT | |
| SCHEMBL19349374 | 0.71 | EPHB3 (0.43) | EPHB3NPC1RAB9ARIPK2LCK | |
| SCHEMBL7815495 | 0.71 | PRKD3 (0.40) | NPC1RAB9AGAAMAPTALDH1A1 | |
| SCHEMBL6744058 | 0.71 | EPHB3 (0.52) | EPHB3NPC1RAB9AGAAMAPT | |
| SCHEMBL7822994 | 0.71 | GAA (0.37) | GAAMAPTALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525480-A | USED FOR DETERMINATION OF HYDROLASES; COLORIMETRIC ANALYSIS | BOEHRINGER MANNHEIM GMBH (DE) | 1996-06-11 | — | — | US | claimed |
| EP-0433855-B1 | N- and O-substituted aminophenol derivatives, intermediates for their preparation, their use as hydrolase substrates, a corresponding assay and diagnostic agents | ROCHE DIAGNOSTICS GMBH (DE) | 2001-03-07 | — | — | EP | disclosed |
| US-5525480-A | USED FOR DETERMINATION OF HYDROLASES; COLORIMETRIC ANALYSIS | BOEHRINGER MANNHEIM GMBH (DE) | 1996-06-11 | — | — | US | disclosed |
| EP-0433853-B1 | Use of 1-aryl semicarbazides for stabilisation of enzyme substrates, corresponding procedure and diagnostic means containing such stabiliser | BOEHRINGER MANNHEIM GMBH (DE) | 1995-08-16 | — | — | EP | disclosed |
| US-5391482-A | Method and diagnostic agent for enzyme substrate stabilization using 1-arylsemicarbazides | BOEHRINGER MANNHEIM GMBH (DE) | 1995-02-21 | — | — | US | disclosed |
| US-5334505-A | For colorimetric determination of hydrolases | BOEHRINGER MANNHEIM GMBH (DE) | 1994-08-02 | — | — | US | disclosed |
| EP-0433853-A1 | Use of 1-aryl semicarbazides for stabilisation of enzyme substrates, corresponding procedure and diagnostic means containing such stabiliser | Roche Diagnostics GmbH (DE) | 1991-06-26 | — | — | EP | disclosed |
| EP-0433855-A2 | N- and O-substituted aminophenol derivatives, intermediates for their preparation, their use as hydrolase substrates, a corresponding assay and diagnostic agents | Roche Diagnostics GmbH (DE) | 1991-06-26 | — | — | EP | disclosed |