Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824624 | 1.00 | MAPT (0.49) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7836691 | 1.00 | MAPT (0.49) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7834448 | 0.89 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7834446 | 0.89 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7837666 | 0.89 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7835487 | 0.88 | SMN1; SMN2 (0.47) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7837173 | 0.88 | SMN1; SMN2 (0.47) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7825235 | 0.88 | KMT2A (0.56) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7839849 | 0.88 | SMN1; SMN2 (0.47) | MAPTSMN1; SMN2TP53GLACYP3A4 | |
| SCHEMBL7835957 | 0.88 | KMT2A (0.56) | MAPTSMN1; SMN2TP53GLACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815105-B1 | HETEROCYCLIC SUBSTITUTED PIPERAZINONE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | AVENTIS PHARMA INC (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-0815105-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINONE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028441-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINONE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-09-19 | — | — | WO | disclosed |