SCHEMBL7824752

SCHEMBL7824752

CCCCCCOc1ccc2c(c1)C(OC)(OC)NC2=N

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.47
PTPN11 Q06124 4/20 0.41
NR5A1 Q13285 1/20 0.41
TSHR P16473 2/20 0.40
PTPN1 P18031 1/20 0.39
THRA P10827 1/20 0.38
THRB P10828 1/20 0.38
HTR1A P08908 4/20 0.38
HTR1D P28221 4/20 0.38
HTR1B P28222 4/20 0.38
TP53 P04637 2/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C9 P11712 1/20 0.38
HTR2A P28223 1/20 0.38
MAPK1 P28482 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7830265 1.00 PDK2 (0.47) PDK2PTPN11NR5A1TSHRPTPN1
SCHEMBL7825876 0.96 PDK2 (0.44) PDK2PTPN11NR5A1PTPN1MAPT
SCHEMBL7825895 0.91 PDK2 (0.44) PDK2HTR1AHTR1BMAPTMAPK1
SCHEMBL7827212 0.90 PDK2 (0.46) PDK2PTPN11NR5A1TSHRPTPN1
SCHEMBL7825985 0.90 PDK2 (0.46) PDK2PTPN11NR5A1TSHRPTPN1
SCHEMBL7827204 0.90 PDK2 (0.42) PDK2PTPN11NR5A1TSHRPTPN1
SCHEMBL7830530 0.90 PDK2 (0.42) PDK2PTPN11NR5A1TSHRPTPN1
SCHEMBL7817014 0.85 PDK2 (0.42) PDK2PTPN11PTPN1MAPT
SCHEMBL7830753 0.85 MEN1 (0.40) PDK2NR5A1TSHRPTPN1KDM4E
SCHEMBL7827909 0.85 PDK2 (0.42) PDK2TP53KDM4ECYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0679640-B1 Carboxylate and heat-sensitive recording material using same MITSUI CHEMICALS INC (JP) 2001-08-08 EP disclosed
US-5691272-A Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, INC. (JP) 1997-11-25 US disclosed
US-5559247-A Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, INC. (JP) 1996-09-24 US disclosed
EP-0679640-A1 Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-11-02 EP disclosed