Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | MGAM | O43451 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 7/20 | 0.51 |
| ▸ | SI | P14410 | 7/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982959 | 0.86 | HTR2A (0.62) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL3656418 | 0.86 | HTR2A (0.62) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL6986747 | 0.86 | HTR2A (0.62) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL26890967 | 0.86 | HTR2A (0.62) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL29611986 | 0.86 | HTR2A (0.62) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| Ammonia Solution, Strong SCHEMBL11124638 | 0.85 | HTR2A (0.60) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL29272546 | 0.85 | HTR2A (0.60) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL27975035 | 0.85 | HTR2A (0.60) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL29272526 | 0.85 | HTR2A (0.60) | HTR2AHTR2CHTR2BGPR84FFAR1 | |
| SCHEMBL29272698 | 0.85 | HTR2A (0.60) | HTR2AHTR2CHTR2BGPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311876-B | Heteroaryl estrogen receptor modulators and uses thereof | 豪夫迈·罗氏有限公司 | 2022-05-03 | — | — | CN | disclosed |
| EP-3472162-B1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2021-11-17 | — | — | EP | disclosed |
| EP-3472162-B1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2021-11-17 | — | — | EP | disclosed |
| US-10654867-B2 | Heteroaryl estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| US-10654867-B2 | Heteroaryl estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2020-05-19 | — | — | US | disclosed |
| EP-3472162-A1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2019-04-24 | — | — | EP | disclosed |
| CN-109311876-A | heteroaryl estrogen receptor modulators and uses thereof | 豪夫迈·罗氏有限公司 | 2019-02-05 | — | — | CN | disclosed |
| US-20180002344-A1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2018-01-04 | — | — | US | disclosed |
| US-20180002344-A1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2018-01-04 | — | — | US | disclosed |
| CN-1738798-A | Indole derivatives as somatostatin agonists or antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2006-02-22 | — | — | CN | disclosed |
| US-6291683-B1 | AS ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-09-18 | — | — | US | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
| EP-0655196-B1 | Agent and method for increasing sugar content and/or decreasing acid content in plant fruit | AGENCY IND SCIENCE TECHN (JP) | 1998-09-16 | — | — | EP | disclosed |
| EP-0652212-B1 | Substituted fluorine-containing beta-indolebutyric acid derivatives, their preparation and their use as plant growth regulators | AGENCY IND SCIENCE TECHN (JP) | 1998-03-11 | — | — | EP | disclosed |
| US-5578552-A | ADJUSTING SWEETNESS OF CITRUS FRUITS | AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY, (JP) | 1996-11-26 | — | — | US | disclosed |
| US-5496794-A | CONTROLLING LENGTH OF SPROUTING ROOTS, ADHESION TO SEEDS | AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0655196-A2 | Agent and method for increasing sugar content and/or decreasing acid content in plant fruit | Agency of Industrial Science and Technology of Ministry of International Trade and Industry (JP) | 1995-05-31 | — | — | EP | disclosed |
| EP-0652212-A1 | Substituted fluorine-containing beta-indolebutyric acid derivatives, their preparation and their use as plant growth regulators | Agency of Industrial Science and Technology of Ministry of International Trade and Industry (JP) | 1995-05-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002344-A1 | HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ESR2, GPER1, ESRRA | HTR2A 273/4885HTR2C 256/4885HTR2B 487/4885 |
| US-10654867-B2 | Heteroaryl estrogen receptor modulators and uses thereof | ESR2, GPER1, ESRRA | HTR2A 273/4885HTR2C 256/4885HTR2B 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.