Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087415 | 0.91 | NTRK1 (0.76) | NTRK1 | |
| SCHEMBL3087650 | 0.84 | NTRK1 (0.74) | NTRK1 | |
| SCHEMBL7833961 | 0.83 | NTRK1 (0.48) | NTRK1ALDH1A1 | |
| SCHEMBL3084738 | 0.82 | NTRK1 (0.60) | NTRK1 | |
| SCHEMBL3082246 | 0.82 | NTRK1 (0.62) | NTRK1HPGD | |
| SCHEMBL3094633 | 0.81 | NTRK1 (0.61) | NTRK1KMT2A | |
| SCHEMBL3096961 | 0.81 | NTRK1 (0.61) | NTRK1HPGD | |
| SCHEMBL3087131 | 0.81 | NTRK1 (0.72) | NTRK1 | |
| SCHEMBL3085037 | 0.79 | NTRK1 (0.59) | NTRK1ALDH1A1 | |
| SCHEMBL3073533 | 0.79 | NTRK1 (0.59) | NTRK1HPGDLMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |