Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.37 |
| ▸ | MPC2 | O95563 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805537 | 0.87 | PPARG (0.53) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL163917 | 0.86 | PPARG (0.66) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| Hydrochloric Acid SCHEMBL2944707 | 0.85 | PPARG (0.66) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL8792213 | 0.84 | PPARG (0.52) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL20579578 | 0.82 | PPARG (0.69) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL7828746 | 0.82 | PPARG (0.69) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL20579732 | 0.82 | PPARG (0.69) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL18541516 | 0.81 | PPARG (0.77) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL5669985 | 0.81 | PPARG (0.77) | PPARGCYP3A4RXRAMPC2CYP2C8 | |
| SCHEMBL18541510 | 0.81 | PPARG (0.77) | PPARGCYP3A4RXRAMPC2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579733-B1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | UPJOHN CO (US) | 2001-06-20 | — | — | EP | claimed |
| US-5441971-A | Antidiabetic agents | THE UPJOHN COMPANY (US) | 1995-08-15 | — | — | US | claimed |
| EP-0579733-B1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | UPJOHN CO (US) | 2001-06-20 | — | — | EP | disclosed |
| US-5441971-A | Antidiabetic agents | THE UPJOHN COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0579733-A1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | PHARMACIA & UPJOHN COMPANY (US) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992018501-A1 | THIAZOLIDINEDIONE DERIVATIVES, PRODUCTION AND USE THEREOF | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |