Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 20/20 | 0.54 |
| ▸ | CDK2 | P24941 | 20/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828279 | 1.00 | CCNE1 (0.54) | CCNE1CDK2CCNE2 | |
| SCHEMBL7820027 | 0.92 | CCNE1 (0.54) | CCNE1CDK2CCNE2 | |
| SCHEMBL7820023 | 0.92 | CCNE1 (0.54) | CCNE1CDK2CCNE2 | |
| SCHEMBL7819717 | 0.85 | CCNE1 (0.60) | CCNE1CDK2CCNE2 | |
| SCHEMBL7819713 | 0.85 | CCNE1 (0.60) | CCNE1CDK2CCNE2 | |
| SCHEMBL7819720 | 0.85 | CCNE1 (0.59) | CCNE1CDK2CCNE2 | |
| SCHEMBL7819722 | 0.85 | CCNE1 (0.59) | CCNE1CDK2CCNE2 | |
| SCHEMBL7819721 | 0.85 | CCNE1 (0.62) | CCNE1CDK2CCNE2 | |
| SCHEMBL7819725 | 0.85 | CCNE1 (0.62) | CCNE1CDK2CCNE2 | |
| SCHEMBL7820012 | 0.83 | CCNE1 (0.61) | CCNE1CDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | claimed |
| US-6307056-B1 | INHIBIT OR MODULATE PROTEIN KINASES, IN PARTICULAR JNK PROTEIN KINASES. | HOFFMAN-LA ROCHE INC. | 2001-10-23 | — | — | US | claimed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | claimed |
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6307056-B1 | INHIBIT OR MODULATE PROTEIN KINASES, IN PARTICULAR JNK PROTEIN KINASES. | HOFFMAN-LA ROCHE INC. | 2001-10-23 | — | — | US | disclosed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |