Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 5/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.63 |
| ▸ | FLT3 | P36888 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | JAK3 | P52333 | 2/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828465 | 1.00 | TLK2 (0.63) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7827890 | 0.87 | PDPK1 (0.69) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7827888 | 0.87 | PDPK1 (0.69) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7819646 | 0.86 | PDPK1 (0.68) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7819649 | 0.86 | PDPK1 (0.68) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7827772 | 0.85 | KDR (0.62) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7830669 | 0.85 | PDPK1 (0.69) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7830665 | 0.85 | PDPK1 (0.69) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7827773 | 0.85 | KDR (0.62) | TLK2PDPK1FLT3KDRAURKB | |
| SCHEMBL7827840 | 0.83 | PDPK1 (0.62) | TLK2PDPK1FLT3KDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | claimed |
| US-6307056-B1 | INHIBIT OR MODULATE PROTEIN KINASES, IN PARTICULAR JNK PROTEIN KINASES. | HOFFMAN-LA ROCHE INC. | 2001-10-23 | — | — | US | claimed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | claimed |
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6307056-B1 | INHIBIT OR MODULATE PROTEIN KINASES, IN PARTICULAR JNK PROTEIN KINASES. | HOFFMAN-LA ROCHE INC. | 2001-10-23 | — | — | US | disclosed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |