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SCHEMBL7828486

SCHEMBL7828486

Cc1ccc(Nc2cc(N3CCOCC3)cc(C(F)(F)F)c2)cc1NC(=O)c1cccc(N(C)CCCN(C)C)c1N

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 5/20 0.47
▸ MAPK14 Q16539 2/20 0.44
▸ BRAF P15056 13/20 0.43
▸ RAF1 P04049 2/20 0.43
▸ LYN P07948 2/20 0.41
▸ TRPV4 Q9HBA0 1/20 0.40
▸ KIT P10721 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4831556 0.91 CSF1R (0.58) CSF1RMAPK14BRAFRAF1LYN
SCHEMBL7825466 0.87 CSF1R (0.47) CSF1RMAPK14BRAFRAF1LYN
SCHEMBL7823001 0.82 CSF1R (0.45) CSF1RMAPK14BRAFRAF1LYN
SCHEMBL4831424 0.81 CSF1R (0.56) CSF1RMAPK14BRAFRAF1LYN
Morpholine SCHEMBL27557450 0.79 BRAF (0.51) CSF1RMAPK14BRAFRAF1KIT
SCHEMBL4829468 0.78 CSF1R (0.59) CSF1RMAPK14BRAFRAF1LYN
SCHEMBL4827685 0.78 MAPK14 (0.60) MAPK14BRAFRAF1
SCHEMBL7822467 0.76 BRAF (0.54) CSF1RMAPK14BRAFRAF1LYN
SCHEMBL7827478 0.76 CSF1R (0.52) CSF1RMAPK14BRAFRAF1LYN
SCHEMBL4831695 0.75 PLAU (0.46) MAPK14BRAFRAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163237-A1 AMIDE DERIVATIVES AstraZeneca AB (SE) 2001-12-19 — — EP disclosed
WO-2000055153-A1 AMIDE DERIVATIVES ASTRAZENECA AB (SE) 2000-09-21 — — WO disclosed