SCHEMBL7828899

SCHEMBL7828899

C=C(C(=O)O)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.63

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.63
SRD5A2 P31213 1/20 0.55
KMO O15229 5/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
KDM4E B2RXH2 1/20 0.47
NPC1 O15118 1/20 0.47
MAPT P10636 1/20 0.47
PKM P14618 1/20 0.47
RAB9A P51151 1/20 0.47
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9812604 0.84 HSP90AA1 (0.49) TSHRSRD5A2KDM4EMAPTSMN1; SMN2
SCHEMBL27793384 0.83 TSHR (0.57) TSHRSRD5A2KMOMEN1KMT2A
SCHEMBL31620838 0.82 MAPT (0.49) TSHRSRD5A2MEN1KMT2ANPC1
SCHEMBL11655118 0.82 TSHR (0.61) TSHRSRD5A2KMOMEN1KMT2A
SCHEMBL28259354 0.80 TDP1 (0.48) TSHRSRD5A2MAOAMAOB
SCHEMBL906513 0.78 TSHR (0.68) TSHRSRD5A2KMOMEN1KMT2A
SCHEMBL11320111 0.78 KMT2A (0.50) TSHRMEN1KMT2AKDM4ENPC1
SCHEMBL29240129 0.78 SRD5A2 (0.46) TSHRSRD5A2KMT2AKDM4EMAPT
SCHEMBL31059293 0.78 KDR (0.49) MAPT
SCHEMBL371998 0.78 TSHR (1.00) TSHRSRD5A2KMOMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109843866-A YAP1 inhibitors targeting YAP1 interaction with OCT4 H·李·莫菲特癌症中心研究有限公司 2019-06-04 CN disclosed
WO-2012142067-A2 FORMULATIONS, SALTS, AND SOLID FORMS OF SUBSTITUTED CYCLOHEXYLMETHANAMINES, PROCESSES FOR PREPARATION, AND USES THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2012-10-18 WO disclosed
WO-2012142067-A2 FORMULATIONS, SALTS, AND SOLID FORMS OF SUBSTITUTED CYCLOHEXYLMETHANAMINES, PROCESSES FOR PREPARATION, AND USES THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2012-10-18 WO disclosed
EP-1009405-A4 PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2001-05-09 EP disclosed
US-6166037-A Pyrrolidine and piperidine modulators of chemokine receptor activity MERCK & CO., INC. (US) 2000-12-26 US disclosed
EP-1009405-A1 PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2000-06-21 EP disclosed
WO-1999009984-A1 PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1999-03-04 WO disclosed
US-4302484-A Polymers crosslinkable by electron beams BAYER AKTIENGESELLSCHAFT (DE) 1981-11-24 US disclosed