Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 7/20 | 0.50 |
| ▸ | FEN1 | P39748 | 7/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.46 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830529 | 0.85 | ERCC5 (0.59) | ERCC5FEN1PTPN1RNASEH1POLB | |
| SCHEMBL7826555 | 0.85 | FEN1 (0.52) | ERCC5FEN1PTPN1RNASEH1RAB9A | |
| SCHEMBL7818349 | 0.84 | ERCC5 (0.51) | ERCC5FEN1PTPN1RNASEH1RAB9A | |
| SCHEMBL7829382 | 0.83 | PDE3B (0.42) | PTPN1MAPK1LMNAPOLB | |
| SCHEMBL7829802 | 0.80 | MAOB (0.45) | MAPK1RAB9AHCAR2LMNA | |
| SCHEMBL4159536 | 0.80 | MAOB (0.45) | MAPK1RAB9AHCAR2 | |
| SCHEMBL7830115 | 0.79 | NR4A2 (0.47) | ERCC5FEN1PTPN1RNASEH1HCAR2 | |
| SCHEMBL7826756 | 0.79 | PTPN1 (0.51) | ERCC5FEN1PTPN1MAPK1RAB9A | |
| SCHEMBL4670644 | 0.79 | HCAR2 (0.39) | MAPK1RAB9AHCAR2LMNAPOLB | |
| SCHEMBL4670641 | 0.79 | HCAR2 (0.39) | MAPK1RAB9AHCAR2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086091-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2001-10-10 | — | — | EP | claimed |
| US-6262055-B1 | SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES | MERCK & CO., INC. | 2001-07-17 | — | — | US | claimed |
| EP-1086091-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999062897-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1086091-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6262055-B1 | SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES | MERCK & CO., INC. | 2001-07-17 | — | — | US | disclosed |
| EP-1086091-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999062897-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |