Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.71 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.64 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378763 | 1.00 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC3ALOX5 | |
| SCHEMBL22190341 | 0.94 | HDAC1 (0.88) | HDAC1HDAC8HDAC2HDAC3HDAC7 | |
| SCHEMBL30060248 | 0.94 | HDAC1 (0.88) | HDAC1HDAC8HDAC2HDAC3HDAC7 | |
| SCHEMBL10362477 | 0.87 | HDAC1 (0.77) | HDAC1HDAC8HDAC2HDAC3HDAC7 | |
| SCHEMBL28024994 | 0.85 | HDAC1 (0.74) | HDAC1HDAC8HDAC2HDAC3HDAC7 | |
| SCHEMBL13783995 | 0.83 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC3HDAC7 | |
| SCHEMBL10439619 | 0.83 | CYP1A2 (0.87) | HDAC1HDAC8HDAC2HDAC3HDAC7 | |
| SCHEMBL10439755 | 0.83 | CYP1A2 (0.87) | HDAC1HDAC8HDAC2HDAC3HDAC7 | |
| SCHEMBL8434872 | 0.83 | CYP1A2 (0.87) | HDAC1HDAC8HDAC2HDAC3HDAC7 | |
| SCHEMBL2536989 | 0.83 | CYP1A2 (0.87) | HDAC1HDAC8HDAC2HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737671-B1 | Aromatic hydroxamic acid compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5804601-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, BACTERIAL OR VIRAL MENINGITIS, DOWN'S SYNDROME AND PARKINSON'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-08 | — | — | US | disclosed |
| EP-0737671-A2 | Aromatic hydroxamic acid compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1996-10-16 | — | — | EP | disclosed |