Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.60 |
| ▸ | RET | P07949 | 5/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.60 |
| ▸ | JAK3 | P52333 | 4/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.60 |
| ▸ | FLT1 | P17948 | 3/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | CSF1R | P07333 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | LTK | P29376 | 2/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.60 |
| ▸ | MST1R | Q04912 | 2/20 | 0.60 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832022 | 1.00 | KDR (0.60) | KDRPDGFRBRETCHEK1JAK3 | |
| SCHEMBL7830665 | 0.81 | PDPK1 (0.69) | KDRPDGFRBRETCHEK1JAK3 | |
| SCHEMBL7830669 | 0.81 | PDPK1 (0.69) | KDRPDGFRBRETCHEK1JAK3 | |
| SCHEMBL6970326 | 0.80 | PDPK1 (0.60) | KDRPDGFRBRETCHEK1JAK3 | |
| SCHEMBL6970332 | 0.80 | PDPK1 (0.60) | KDRPDGFRBRETCHEK1JAK3 | |
| SCHEMBL7830171 | 0.78 | CCNE1 (0.71) | — | |
| SCHEMBL7830168 | 0.78 | CCNE1 (0.71) | — | |
| SCHEMBL16231610 | 0.76 | PDPK1 (0.61) | KDRPDGFRBRETCHEK1JAK3 | |
| SCHEMBL5728638 | 0.75 | PDPK1 (1.00) | KDRPDGFRBRETCHEK1JAK3 | |
| SCHEMBL5728634 | 0.75 | PDPK1 (1.00) | KDRPDGFRBRETCHEK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | claimed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | claimed |
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6307056-B1 | INHIBIT OR MODULATE PROTEIN KINASES, IN PARTICULAR JNK PROTEIN KINASES. | HOFFMAN-LA ROCHE INC. | 2001-10-23 | — | — | US | disclosed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |