SCHEMBL7832407

SCHEMBL7832407

N#Cc1ccc(Cn2cncc2CNC2CCN(Cc3ccccc3)CC2)cc1

nearest known ligand 0.68

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FNTA P49354 20/20 0.68
FNTB P49356 20/20 0.68
PGGT1B P53609 16/20 0.68
KCNH2 Q12809 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7839148 0.99 FNTA (0.67) FNTAFNTBPGGT1BKCNH2
SCHEMBL7848543 0.89 FNTA (0.68) FNTAFNTBPGGT1BKCNH2
Hydrochloric Acid SCHEMBL7839383 0.88 FNTA (0.67) FNTAFNTBPGGT1BKCNH2
SCHEMBL7838215 0.84 FNTA (0.59) FNTAFNTBPGGT1BKCNH2
Hydrochloric Acid SCHEMBL7841805 0.84 FNTA (0.62) FNTAFNTBPGGT1BKCNH2
Hydrochloric Acid SCHEMBL7848061 0.84 FNTA (0.59) FNTAFNTBPGGT1BKCNH2
SCHEMBL7698995 0.83 FNTA (0.67) FNTAFNTBPGGT1BKCNH2
SCHEMBL7698998 0.83 FNTA (0.67) FNTAFNTBPGGT1BKCNH2
SCHEMBL7934029 0.81 FNTA (0.82) FNTAFNTBPGGT1BKCNH2
SCHEMBL7937393 0.81 FNTA (0.82) FNTAFNTBPGGT1BKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0944388-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2001-08-16 EP claimed
US-6248756-B1 Inhibitors of farnesyl-protein transferase MERCK & CO., INC. 2001-06-19 US claimed
EP-0944388-A2 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 1999-09-29 EP claimed
WO-1997038665-A2 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1997-10-23 WO claimed
EP-0944388-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2001-08-16 EP disclosed
US-6248756-B1 Inhibitors of farnesyl-protein transferase MERCK & CO., INC. 2001-06-19 US disclosed
EP-0944388-A2 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 1999-09-29 EP disclosed
US-5891889-A Inhibitors of farnesyl-protein transferase MERCK & CO., INC. (US) 1999-04-06 US disclosed
WO-1997038665-A2 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1997-10-23 WO disclosed