Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR2A | P27037 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3084312 | 0.93 | ACVR2A (0.42) | ACVR2ATGFBR2MEN1KMT2A | |
| SCHEMBL3097457 | 0.79 | KMT2A (0.37) | POLBMEN1KMT2AP2RX7RAB9A | |
| SCHEMBL3096984 | 0.79 | ACVR2A (0.46) | ACVR2ATGFBR2MEN1KMT2ARAB9A | |
| SCHEMBL3085677 | 0.79 | ACVR2A (0.43) | ACVR2ATGFBR2KDM4EPOLBMEN1 | |
| SCHEMBL7830660 | 0.78 | PDGFRB (0.38) | ACVR2ATGFBR2KDM4EPOLBMEN1 | |
| SCHEMBL3090565 | 0.77 | KDR (0.41) | ACVR2ATGFBR2HSD17B13ALDH1A1HTT | |
| SCHEMBL3078448 | 0.76 | ACVR2A (0.44) | ACVR2ATGFBR2MEN1KMT2A | |
| SCHEMBL4851673 | 0.74 | KDR (0.41) | ACVR2ATGFBR2KDM4EPOLBMEN1 | |
| SCHEMBL3087321 | 0.74 | KDR (0.42) | ACVR2ATGFBR2MEN1KMT2ALMNA | |
| SCHEMBL3073928 | 0.73 | ACVR2A (0.44) | ACVR2ATGFBR2MEN1KMT2AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |