Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083306 | 0.93 | PLK4 (0.55) | ALOX15HSD17B10PLK4AURKAEPHB6 | |
| SCHEMBL378500 | 0.91 | PLK4 (0.58) | ALOX15HSD17B10PLK4AURKAEPHB6 | |
| SCHEMBL378409 | 0.90 | MAPK9 (0.48) | ALOX15HSD17B10PLK4AURKAEPHB6 | |
| SCHEMBL378523 | 0.85 | PLK4 (0.46) | ALOX15HSD17B10PLK4AURKAEPHB6 | |
| SCHEMBL4846631 | 0.85 | KDR (0.56) | ALOX15HSD17B10PLK4AURKAEPHB6 | |
| SCHEMBL378606 | 0.84 | PLK4 (0.42) | ALOX15HSD17B10PLK4AURKAEPHB6 | |
| SCHEMBL3082012 | 0.84 | KDR (0.59) | ALOX15HSD17B10PLK4AURKAEPHB6 | |
| SCHEMBL3087331 | 0.83 | KDR (0.58) | ALOX15HSD17B10PLK4AURKAEPHB6 | |
| SCHEMBL5351091 | 0.83 | KDR (0.68) | PLK4AURKAEPHB6RIPK2STK10 | |
| SCHEMBL3088039 | 0.83 | KDR (0.60) | ALOX15HSD17B10PLK4AURKAEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |