Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 10/20 | 0.75 |
| ▸ | AKR1C1 | Q04828 | 6/20 | 0.75 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.75 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847362 | 1.00 | AKR1C3 (0.75) | AKR1C3AKR1C1AKR1C2PTGS2ALDH1A1 | |
| SCHEMBL7832711 | 1.00 | AKR1C3 (0.75) | AKR1C3AKR1C1AKR1C2PTGS2ALDH1A1 | |
| SCHEMBL6514404 | 0.88 | AKR1C3 (0.57) | AKR1C3AKR1C1AKR1C2ALDH1A1HTT | |
| SCHEMBL6514407 | 0.88 | AKR1C3 (0.57) | AKR1C3AKR1C1AKR1C2ALDH1A1HTT | |
| SCHEMBL7842236 | 0.86 | AKR1C3 (1.00) | AKR1C3AKR1C1AKR1C2PTGS2ALDH1A1 | |
| SCHEMBL7842239 | 0.86 | AKR1C3 (1.00) | AKR1C3AKR1C1AKR1C2PTGS2ALDH1A1 | |
| SCHEMBL7844072 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C1AKR1C2PTGS2ALDH1A1 | |
| SCHEMBL7844074 | 0.85 | AKR1C3 (1.00) | AKR1C3AKR1C1AKR1C2PTGS2ALDH1A1 | |
| SCHEMBL3040559 | 0.85 | AKR1C3 (0.75) | AKR1C3AKR1C1AKR1C2PTGS2ALDH1A1 | |
| SCHEMBL3040564 | 0.85 | AKR1C3 (0.75) | AKR1C3AKR1C1AKR1C2PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |