Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 17/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.46 |
| ▸ | TSHR | P16473 | 6/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.43 |
| ▸ | USP2 | O75604 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27321613 | 0.81 | CYP1A2 (0.47) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL12930107 | 0.76 | PDE10A (0.41) | CYP1A2TSHRHSD17B10MEN1KMT2A | |
| SCHEMBL887595 | 0.74 | CYP1A2 (0.50) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL1050215 | 0.73 | BRD4 (0.36) | ALDH1A1 | |
| SCHEMBL7831798 | 0.73 | HSD17B10 (0.42) | ALDH1A1HSD17B10MEN1KMT2AMAPK1 | |
| SCHEMBL7822684 | 0.73 | HPGD (0.42) | CYP1A2TSHRCYP2C9HSD17B10USP2 | |
| SCHEMBL23346841 | 0.73 | CYP1A2 (0.49) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL14879948 | 0.73 | CYP1A2 (0.49) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL25994071 | 0.72 | CYP1A2 (0.47) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 | |
| SCHEMBL28341211 | 0.72 | CYP1A2 (0.46) | CYP1A2CYP3A4TSHRCLK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676398-B1 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6117893-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-1022274-A1 | Oxazolidinedione and Thiazolidinedione derivatves, their preparation and their use | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-5977365-A | HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5624935-A | ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS | SANKYO COMPANY, LIMITED | 1997-04-29 | — | — | US | disclosed |
| EP-0676398-A2 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1995-10-11 | — | — | EP | disclosed |