Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163118 | 1.00 | CHRNA7 (0.39) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL1741150 | 0.85 | TSHR (0.38) | LMNAKDM4E | |
| SCHEMBL1741641 | 0.85 | TSHR (0.38) | LMNAKDM4E | |
| SCHEMBL7978317 | 0.79 | POLB (0.36) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL7977010 | 0.79 | POLB (0.36) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL7978320 | 0.79 | POLB (0.36) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL7834891 | 0.79 | POLB (0.36) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL7836651 | 0.79 | POLB (0.36) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL7822919 | 0.79 | POLB (0.36) | CHRNA7L3MBTL1TDP1NPC1RAB9A | |
| SCHEMBL7822922 | 0.79 | POLB (0.36) | CHRNA7L3MBTL1TDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984961-B1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143751-A | Pyridine derivatives and pharmaceutical compositions containing them | ASTRAZENECA UK LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |
| EP-0984961-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998043971-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-08 | — | — | WO | disclosed |