Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834072 | 1.00 | HRH3 (0.44) | HRH3SPHK2DRD2DRD3KDM4E | |
| Hydrochloric Acid SCHEMBL7844257 | 0.99 | HRH3 (0.43) | HRH3SPHK2DRD2DRD3KDM4E | |
| Hydrochloric Acid SCHEMBL7844259 | 0.99 | HRH3 (0.43) | HRH3SPHK2DRD2DRD3KDM4E | |
| SCHEMBL7845283 | 0.88 | SPHK2 (0.42) | HRH3SPHK2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7845285 | 0.88 | SPHK2 (0.42) | HRH3SPHK2KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7842006 | 0.87 | SPHK2 (0.42) | HRH3SPHK2KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7842009 | 0.87 | SPHK2 (0.42) | HRH3SPHK2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7834939 | 0.83 | SPHK2 (0.44) | SPHK2NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL7834940 | 0.83 | SPHK2 (0.44) | SPHK2NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL7836178 | 0.83 | KDM4E (0.39) | SPHK2KDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767790-B1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5840732-A | ANTIDIABETIC AGENTS, AUTOIMMUNE DISEASES OR IMMUNOSUPPRESSANTS | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 1998-11-24 | — | — | US | disclosed |
| EP-0767790-A1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-04-16 | — | — | EP | disclosed |
| WO-1995035296-A1 | CONDENSED IMIDAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-12-28 | — | — | WO | disclosed |