Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | TNFRSF1A | P19438 | 7/20 | 0.53 |
| ▸ | KRAS | P01116 | 1/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.47 |
| ▸ | TUBB | P07437 | 2/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834270 | 1.00 | ABCB1 (0.56) | ABCB1ABCG2TNFRSF1AKRASTUBB4A | |
| SCHEMBL7832784 | 0.91 | ABCB1 (0.58) | ABCB1ABCG2TNFRSF1AKRASTUBB4A | |
| SCHEMBL7832790 | 0.91 | ABCB1 (0.58) | ABCB1ABCG2TNFRSF1AKRASTUBB4A | |
| SCHEMBL7835331 | 0.85 | TNFRSF1A (0.58) | ABCB1ABCG2TNFRSF1AKRASTUBB4A | |
| SCHEMBL7835322 | 0.85 | TNFRSF1A (0.58) | ABCB1ABCG2TNFRSF1AKRASTUBB4A | |
| SCHEMBL7837901 | 0.84 | KRAS (0.53) | ABCB1ABCG2TNFRSF1AKRAS | |
| SCHEMBL7837907 | 0.84 | KRAS (0.53) | ABCB1ABCG2TNFRSF1AKRAS | |
| SCHEMBL7836759 | 0.83 | TUBB1 (0.57) | ABCB1ABCG2TNFRSF1AKRASTUBB4A | |
| SCHEMBL7836770 | 0.83 | TUBB1 (0.57) | ABCB1ABCG2TNFRSF1AKRASTUBB4A | |
| SCHEMBL7824299 | 0.83 | MEN1 (0.64) | ABCB1ABCG2TNFRSF1AKRASTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680950-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0680950-A1 | PROPENONE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-08 | — | — | EP | disclosed |