Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833355 | 0.85 | HTT (0.41) | POLBHPGDHTTSMN1; SMN2PTAFR | |
| SCHEMBL7978664 | 0.82 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL7977066 | 0.82 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL7976881 | 0.82 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL7980129 | 0.82 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL7976863 | 0.82 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL7966197 | 0.82 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL7822087 | 0.80 | POLB (0.36) | POLBHPGDCHRNA7MEN1KMT2A | |
| SCHEMBL8145416 | 0.80 | POLB (0.36) | POLBHPGDCHRNA7MEN1KMT2A | |
| SCHEMBL7966401 | 0.80 | POLB (0.41) | POLBHPGDHTTSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984961-B1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | claimed |
| EP-0984961-B1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143751-A | Pyridine derivatives and pharmaceutical compositions containing them | ASTRAZENECA UK LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |