Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLA1 | P09884 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201283 | 0.89 | KCNH2 (0.54) | MELKKCNH2POLA1ALDH1A1F10 | |
| SCHEMBL6665763 | 0.85 | KCNH2 (0.54) | MELKKCNH2POLA1ALDH1A1F10 | |
| SCHEMBL7843275 | 0.82 | QPCT (0.39) | ALDH1A1EGFR | |
| SCHEMBL6667972 | 0.79 | TRPV1 (0.40) | ALDH1A1EGFR | |
| SCHEMBL6669690 | 0.78 | KCNH2 (0.50) | KCNH2POLA1ALDH1A1F10NPC1 | |
| SCHEMBL6713757 | 0.77 | EGLN1 (0.51) | KCNH2POLA1ALDH1A1PDE1BNPC1 | |
| SCHEMBL6670929 | 0.76 | POLA1 (0.50) | KCNH2POLA1ALDH1A1NPC1RAB9A | |
| SCHEMBL6339478 | 0.75 | KCNH2 (0.51) | KCNH2LMNAPOLA1F10 | |
| SCHEMBL6200011 | 0.75 | KCNH2 (0.53) | KCNH2POLA1ALDH1A1F10 | |
| SCHEMBL6770778 | 0.75 | KCNH2 (0.53) | KCNH2POLA1ALDH1A1F10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140850-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6248739-B1 | DNA POLYMERASE INHIBITORS EFFECTIVE AGAINST HERPESVIRUSES | PHARMACIA & UPJOHN COMPANY | 2001-06-19 | — | — | US | disclosed |
| WO-2000040561-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |