Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 19/20 | 0.82 |
| ▸ | EGFR | P00533 | 6/20 | 0.63 |
| ▸ | CSK | P41240 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 5/20 | 0.61 |
| ▸ | ABL2 | P42684 | 5/20 | 0.61 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | TPO | P07202 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842681 | 0.97 | SRC (0.86) | SRCEGFRCSKKDRABL1 | |
| SCHEMBL7841567 | 0.91 | SRC (0.75) | SRCEGFRCSKKDRABL1 | |
| SCHEMBL7835317 | 0.90 | SRC (1.00) | SRCEGFRCSKKDRABL1 | |
| SCHEMBL7845672 | 0.89 | SRC (0.89) | SRCEGFRCSKKDRABL1 | |
| SCHEMBL7844402 | 0.86 | SRC (0.75) | SRCEGFRKDRABL1ABL2 | |
| SCHEMBL7835070 | 0.85 | SRC (0.73) | SRCEGFRCSKKDRABL1 | |
| Dimethylamine SCHEMBL7844416 | 0.84 | SRC (0.76) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7842183 | 0.84 | SRC (0.70) | SRCEGFRCSKKDRABL1 | |
| SCHEMBL7835156 | 0.84 | SRC (0.72) | SRCEGFRCSKKDRABL1 | |
| SCHEMBL7844411 | 0.84 | SRC (0.72) | SRCEGFRABL1ABL2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |