Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 10/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 4/20 | 0.39 |
| ▸ | TDO2 | P48775 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838016 | 0.94 | MALT1 (0.43) | TOP2AMALT1IDO1TDO2DDB1 | |
| SCHEMBL7808475 | 0.86 | TOP2A (0.47) | TOP2AMALT1IDO1TDO2 | |
| SCHEMBL7810394 | 0.83 | TOP2A (0.45) | TOP2AIDO1TDO2 | |
| SCHEMBL7810012 | 0.80 | TOP2A (0.45) | TOP2AMALT1IDO1TDO2 | |
| SCHEMBL7810494 | 0.80 | TOP2A (0.40) | TOP2AMALT1IDO1 | |
| SCHEMBL7816428 | 0.79 | TOP2A (0.45) | TOP2AIDO1TDO2 | |
| SCHEMBL7816796 | 0.78 | TOP2A (0.44) | TOP2AMALT1IDO1DDB1CRBN | |
| SCHEMBL7804755 | 0.78 | TOP2A (0.44) | TOP2AMALT1IDO1DDB1CRBN | |
| SCHEMBL7820210 | 0.78 | KAT2B (0.45) | TOP2AMALT1IDO1TDO2 | |
| SCHEMBL7819756 | 0.77 | TOP2A (0.45) | TOP2AMALT1IDO1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |