Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.64 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.59 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KLK7 | P49862 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873735 | 1.00 | PREP (0.64) | PREPACE2CTRB1NPSR1TMEM97 | |
| SCHEMBL8272821 | 0.91 | PREP (0.65) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL13532966 | 0.91 | PREP (0.65) | PREPACE2CTRB1NPSR1TSHR | |
| Hydrochloric Acid SCHEMBL2437118 | 0.90 | PREP (0.64) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL19258607 | 0.90 | PREP (0.63) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL9092047 | 0.89 | PREP (0.62) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL9092056 | 0.89 | PREP (0.62) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL16419544 | 0.88 | PREP (0.67) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL9872401 | 0.88 | PREP (0.61) | PREPACE2CTRB1NPSR1TMEM97 | |
| Hydrochloric Acid SCHEMBL30300752 | 0.88 | PREP (0.61) | PREPACE2CTRB1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663912-B1 | HETEROCYCLIC ETHER COMPOUNDS THAT ENHANCE COGNITIVE FUNCTION | ABBOTT LAB (US) | 2001-12-12 | — | — | EP | disclosed |
| US-5948793-A | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release | ABBOTT LABORATORIES (US) | 1999-09-07 | — | — | US | disclosed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |
| US-5051444-A | Pyrrolidine derivatives as anti-amnesia agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1991-09-24 | — | — | US | disclosed |
| US-4880827-A | Pyrrolidine derivatives having inhibitory action for proline specific endopepidase | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0238319-A1 | Pyrrolidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-09-23 | — | — | EP | disclosed |