Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 15/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 15/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 15/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 15/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 15/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 14/20 | 0.71 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | BRD4 | O60885 | 1/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | LTA4H | P09960 | 1/20 | 0.71 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659812 | 0.98 | HDAC8 (0.74) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL7563467 | 0.98 | HDAC8 (0.74) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL4403514 | 0.98 | HDAC8 (0.74) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL1162572 | 0.98 | HDAC8 (0.74) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL4594453 | 0.94 | HDAC8 (0.68) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL517309 | 0.92 | HDAC4 (0.81) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL22661266 | 0.92 | HDAC8 (0.66) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL22661249 | 0.92 | HDAC8 (0.66) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL6669511 | 0.90 | HDAC4 (0.85) | HDAC8HDAC6HDAC2HDAC4HDAC1 | |
| SCHEMBL1065393 | 0.90 | HDAC4 (0.85) | HDAC8HDAC6HDAC2HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454501-B1 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | SANKYO CO (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0839812-A1 | Preparation of benzylthiazolidine derivatives | Sankyo Company Limited (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5387596-A | Treating arteriosclerosis | SANKYO COMPANY, LIMITED (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0454501-A2 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | Sankyo Company Limited (JP) | 1991-10-30 | — | — | EP | disclosed |