Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.55 |
| ▸ | GRM1 | Q13255 | 11/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL616396 | 0.84 | ATR (0.51) | GRM5GRM1 | |
| SCHEMBL4847387 | 0.81 | GRM1 (0.50) | GRM5GRM1PDK4PDE10ANAMPT | |
| SCHEMBL949070 | 0.80 | GRM1 (0.48) | GRM5GRM1PDK4NAMPTCNR1 | |
| SCHEMBL7840654 | 0.78 | GRM1 (0.53) | GRM5GRM1PDK4PDE10ANAMPT | |
| SCHEMBL6621771 | 0.78 | PDE10A (0.60) | GRM5GRM1PDK4PDE10ANAMPT | |
| SCHEMBL2239831 | 0.77 | NAMPT (0.66) | GRM5GRM1PDK4NAMPTHTR6 | |
| SCHEMBL1198787 | 0.77 | PDE10A (0.56) | GRM5GRM1PDK4DRD2DRD4 | |
| SCHEMBL29591544 | 0.77 | GRM1 (0.59) | GRM5GRM1PDK4PDE10ANAMPT | |
| SCHEMBL7837563 | 0.77 | GRM1 (0.59) | GRM5GRM1PDK4PDE10ANAMPT | |
| SCHEMBL30308912 | 0.77 | GRM1 (0.64) | GRM5GRM1PDK4PDE10ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087962-A4 | PREPARATION OF HETEROARYL COMPOUNDS | LILLY CO ELI (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1087962-A1 | PREPARATION OF HETEROARYL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065896-A1 | PREPARATION OF HETEROARYL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |