Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.51 |
| ▸ | FLT1 | P17948 | 6/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838293 | 0.88 | KDR (0.50) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL7829174 | 0.87 | KDR (0.49) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL3380944 | 0.81 | KDR (0.65) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL7827590 | 0.80 | KDR (0.48) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL377856 | 0.80 | KDR (0.68) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL3091090 | 0.80 | KDR (0.50) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL7827223 | 0.79 | KDR (0.43) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL4208736 | 0.78 | KDR (0.61) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL3085126 | 0.77 | KDR (0.58) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL3091053 | 0.77 | KDR (0.57) | KDRPDGFRBFLT1PLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |