Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 4/20 | 0.50 |
| ▸ | FNTB | P49356 | 4/20 | 0.50 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839818 | 0.93 | FNTA (0.48) | NPSR1MAPK1GAAALDH1A1LMNA | |
| SCHEMBL7838097 | 0.91 | FNTA (0.55) | NPSR1MAPK1GAAALDH1A1LMNA | |
| SCHEMBL7839865 | 0.89 | FNTA (0.53) | NPSR1MAPK1GAAALDH1A1LMNA | |
| SCHEMBL446699 | 0.88 | FNTA (0.53) | NPSR1GAALMNAL3MBTL1MEN1 | |
| SCHEMBL7840263 | 0.88 | FNTA (0.53) | NPSR1MAPK1GAAALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL7841379 | 0.88 | FNTA (0.53) | NPSR1MAPK1GAAALDH1A1LMNA | |
| SCHEMBL7856913 | 0.87 | FNTA (0.61) | GAAALDH1A1LMNAL3MBTL1RAB9A | |
| SCHEMBL7839572 | 0.87 | FNTA (0.55) | NPSR1MAPK1GAAALDH1A1LMNA | |
| SCHEMBL7839131 | 0.85 | FNTA (0.51) | NPSR1MAPK1GAAALDH1A1LMNA | |
| SCHEMBL7848346 | 0.84 | FNTA (0.49) | NPSR1MAPK1GAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |