Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771533 | 0.94 | MAPT (0.46) | MAPTALDH1A1L3MBTL1NPSR1CTSB | |
| SCHEMBL4764313 | 0.84 | CNR2 (0.42) | MAPTALDH1A1CTSBCTSSCTSL | |
| SCHEMBL4771518 | 0.80 | SPHK1 (0.37) | MAPTALDH1A1L3MBTL1CTSBCTSS | |
| SCHEMBL13613119 | 0.75 | MAPT (0.50) | MAPTALDH1A1L3MBTL1NPSR1CTSB | |
| SCHEMBL5525539 | 0.75 | MAPT (0.44) | MAPTALDH1A1L3MBTL1NPSR1CTSB | |
| SCHEMBL27760068 | 0.75 | SPHK1 (0.52) | MAPTALDH1A1L3MBTL1CNR2 | |
| SCHEMBL29186066 | 0.74 | MAPT (0.49) | MAPTALDH1A1L3MBTL1NPSR1CTSB | |
| SCHEMBL1115241 | 0.72 | MAPT (0.51) | MAPTALDH1A1L3MBTL1NPSR1CTSB | |
| SCHEMBL29186053 | 0.72 | MAPT (0.51) | MAPTALDH1A1L3MBTL1NPSR1CTSB | |
| SCHEMBL12323501 | 0.70 | MAPT (0.45) | MAPTALDH1A1L3MBTL1NPSR1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1094816-A4 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1094816-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001389-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-01-13 | — | — | WO | disclosed |