Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.50 |
| ▸ | FBP1 | P09467 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849876 | 0.85 | EPHA2 (0.56) | EGFREPHA2KDRERBB2FBP1 | |
| SCHEMBL7852031 | 0.83 | EGFR (0.63) | EGFRKDRERBB2FBP1KDM4E | |
| SCHEMBL7847659 | 0.82 | EGFR (0.60) | EGFRKDRERBB2FBP1KDM4E | |
| SCHEMBL1418072 | 0.82 | EGFR (0.63) | EGFRERBB2GAKSRCERBB4 | |
| SCHEMBL1418070 | 0.82 | EGFR (0.63) | EGFRERBB2GAKSRCERBB4 | |
| SCHEMBL7839286 | 0.82 | EGFR (0.61) | EGFRKDRERBB2FBP1KDM4E | |
| SCHEMBL7839969 | 0.82 | EGFR (0.59) | EGFREPHA2KDRERBB2FBP1 | |
| SCHEMBL7848643 | 0.80 | EGFR (0.56) | EGFREPHA2KDRERBB2FBP1 | |
| SCHEMBL7847631 | 0.78 | EGFR (0.57) | EGFRKDRERBB2FBP1KDM4E | |
| SCHEMBL7848404 | 0.78 | EGFR (0.59) | EGFRKDRERBB2FBP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |