Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986412 | 0.87 | GAA (0.57) | GAAPOLBHPGDDNM1KDM4E | |
| SCHEMBL12460089 | 0.85 | HPGD (0.51) | GAAHPGDDNM1LMNAHDAC1 | |
| SCHEMBL9393524 | 0.84 | GAA (0.54) | GAAHPGDDNM1KDM4ELMNA | |
| SCHEMBL27586244 | 0.83 | GAA (0.53) | GAAPOLBHPGDDNM1KDM4E | |
| SCHEMBL11966140 | 0.82 | HDAC1 (0.54) | GAAPOLBHPGDDNM1HDAC1 | |
| SCHEMBL22403771 | 0.81 | HPGD (0.54) | POLBHPGD | |
| SCHEMBL7508128 | 0.80 | GAA (0.60) | GAAPOLBHPGDKDM4ELMNA | |
| SCHEMBL15109630 | 0.80 | KDM4E (0.74) | POLBHPGDKDM4ELMNACYP2C19 | |
| SCHEMBL13806431 | 0.79 | POLB (0.51) | POLBHPGDKDM4ELMNAHDAC1 | |
| SCHEMBL16425208 | 0.79 | POLB (0.51) | GAAPOLBHPGDKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1330638-A | Substituted benzo [ de ] isoquinoline-1, 3-diones | MERCK PATENT GMBH (DE) | 2002-01-09 | — | — | CN | disclosed |
| EP-1144381-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000032577-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-08 | — | — | WO | disclosed |