Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839873 | 1.00 | EDNRA (0.45) | EDNRA | |
| SCHEMBL8153368 | 0.91 | EDNRA (0.56) | EDNRA | |
| SCHEMBL8153365 | 0.91 | EDNRA (0.56) | EDNRA | |
| SCHEMBL7840888 | 0.91 | EDNRA (0.48) | EDNRA | |
| SCHEMBL7831595 | 0.91 | EDNRA (0.48) | EDNRA | |
| SCHEMBL7840885 | 0.91 | EDNRA (0.48) | EDNRA | |
| SCHEMBL7831596 | 0.91 | EDNRA (0.48) | EDNRA | |
| SCHEMBL7841148 | 0.89 | EDNRA (0.46) | EDNRA | |
| SCHEMBL7841149 | 0.89 | EDNRA (0.46) | EDNRA | |
| SCHEMBL7841634 | 0.88 | EDNRA (0.59) | EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882030-B1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GMBH (DE) | 2001-09-12 | — | — | EP | disclosed |
| EP-0882030-A1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GmbH (DE) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997030982-A1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-08-28 | — | — | WO | disclosed |