Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619001 | 0.96 | EDNRB (0.55) | EDNRBEDNRA | |
| SCHEMBL7839524 | 0.94 | EDNRB (0.59) | EDNRBEDNRA | |
| SCHEMBL7840944 | 0.94 | EDNRB (0.67) | EDNRBEDNRA | |
| SCHEMBL7839919 | 0.93 | EDNRB (0.62) | EDNRBEDNRA | |
| SCHEMBL7842050 | 0.92 | EDNRB (0.62) | EDNRBEDNRA | |
| SCHEMBL7843797 | 0.90 | EDNRB (0.59) | EDNRBEDNRA | |
| SCHEMBL7831939 | 0.90 | EDNRB (0.61) | EDNRBEDNRA | |
| SCHEMBL7840780 | 0.89 | EDNRB (0.61) | EDNRBEDNRA | |
| SCHEMBL7843055 | 0.89 | EDNRB (0.58) | EDNRBEDNRA | |
| SCHEMBL8620747 | 0.88 | EDNRB (0.57) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882030-B1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GMBH (DE) | 2001-09-12 | — | — | EP | disclosed |
| US-6017939-A | 2,1,3-benzothia(OXA)diazole derivatives having an endothelin receptor antagonistic effect | MERCK PATENT GESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| WO-1998042702-A1 | ENDOTHELIN-RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-10-01 | — | — | WO | disclosed |