Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.93 |
| ▸ | CSF1R | P07333 | 5/20 | 0.66 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | TEK | Q02763 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897754 | 0.96 | BRAF (1.00) | BRAFCSF1RKITHSF1KDR | |
| SCHEMBL7840187 | 0.94 | BRAF (0.91) | BRAFCSF1RKITHSF1KDR | |
| SCHEMBL22364997 | 0.90 | BRAF (0.88) | BRAFCSF1RKITHSF1KDR | |
| SCHEMBL5897226 | 0.90 | BRAF (0.87) | BRAFCSF1RKITHSF1TRPV1 | |
| SCHEMBL6979265 | 0.84 | BRAF (0.77) | BRAFCSF1RHSF1RAF1KDM4E | |
| SCHEMBL5897251 | 0.84 | BRAF (0.76) | BRAFCSF1RHSF1RAF1KDM4E | |
| SCHEMBL5000987 | 0.82 | BRAF (0.78) | BRAFCSF1RKITKDRRAF1 | |
| SCHEMBL5897048 | 0.82 | BRAF (0.71) | BRAFCSF1RHSF1PDGFRBPDGFRA | |
| SCHEMBL5897487 | 0.81 | CSF1R (0.81) | BRAFCSF1RHSF1RAF1KDM4E | |
| SCHEMBL5897118 | 0.81 | BRAF (0.69) | BRAFCSF1RHSF1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102750-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007991-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |