Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nebentan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA known ✓ | P25101 | 18/20 | 0.60 |
| ▸ | EDNRB | P24530 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nebentan SCHEMBL7840278 | 0.98 | EDNRA (0.58) | EDNRAEDNRB | |
| Nebentan SCHEMBL29372258 | 0.98 | EDNRA (0.59) | EDNRAEDNRB | |
| Nebentan SCHEMBL5272291 | 0.98 | EDNRA (0.59) | EDNRAEDNRB | |
| Nebentan SCHEMBL5272299 | 0.98 | EDNRA (0.59) | EDNRAEDNRB | |
| Nebentan SCHEMBL7201971 | 0.97 | EDNRA (0.58) | EDNRAEDNRB | |
| Nebentan SCHEMBL7839734 | 0.97 | EDNRA (0.58) | EDNRAEDNRB | |
| Nebentan SCHEMBL5711743 | 0.97 | EDNRA (0.58) | EDNRAEDNRB | |
| Nebentan SCHEMBL5272543 | 0.94 | EDNRA (0.61) | EDNRAEDNRB | |
| Nebentan SCHEMBL5272550 | 0.94 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL7841517 | 0.92 | EDNRA (0.57) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882719-B1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMA CO LTD (JP) | 2001-05-16 | — | — | EP | disclosed |
| US-6083955-A | HAVING A HIGH AFFINITY FOR DRUGS, ESPECIALLY ENDOSERINE RECEPTORS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |
| EP-0882719-A1 | ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |