⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681748 | 0.75 | CTSA (0.50) | — | |
| SCHEMBL268599 | 0.75 | CTSA (0.50) | — | |
| SCHEMBL11658682 | 0.75 | — | — | |
| SCHEMBL3061757 | 0.75 | CTSA (0.50) | — | |
| Phosphorylisopropane SCHEMBL82996 | 0.75 | — | — | |
| SCHEMBL12240712 | 0.74 | — | — | |
| SCHEMBL3822462 | 0.74 | — | — | |
| SCHEMBL13020373 | 0.73 | — | — | |
| SCHEMBL10579482 | 0.73 | — | — | |
| Phosphorylisopropane SCHEMBL17670024 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102215-A2 | 4'-DIFLUOROMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF INFLUENZA RNA REPLICATION | Riboscience LLC (US) | 2016-12-14 | — | — | EP | claimed |
| WO-2015120237-A2 | 4'-DIFLUOROMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF INFLUENZA RNA REPLICATION | RIBOSCIENCE LLC (US) | 2015-08-13 | — | — | WO | claimed |
| US-11773126-B2 | Substituted nucleosides, nucleotides and analogs thereof | Janssen Pharmaceuticals, Inc. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20230201236-A1 | SPIROCYCLIC NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF HEPATITIS E | Janssen Pharmaceuticals, Inc. | 2023-06-29 | — | — | US | disclosed |
| US-20230201239-A1 | ALKYNYL NUCLEOSIDE ANALOGS FOR TREATMENT OF HEPATITIS E | Janssen Pharmaceuticals, Inc. | 2023-06-29 | — | — | US | disclosed |
| US-20230167151-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-01 | — | — | US | disclosed |
| US-20230159449-A1 | LIPID FORMULATIONS CONTAINING NUCLEIC ACIDS AND METHODS OF TREATMENT FOR CYSTIC FIBROSIS | ARCTURUS THERAPEUTICS, INC. | 2023-05-25 | — | — | US | disclosed |
| CN-105979951-B | 4' -difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication | 里博科学有限责任公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-111194217-A | 4 '-fluoro-2' -methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication | 里伯赛恩斯有限责任公司 | 2020-05-22 | — | — | CN | disclosed |
| WO-2019032607-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2019-02-14 | — | — | WO | disclosed |
| US-20180194793-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen Biopharma, Inc. | 2018-07-12 | — | — | US | disclosed |
| US-20130253181-A1 | METHODS OF PREPARING SUBSTITUTED NUCLEOTIDE ANALOGS | VERTEX PHARMACEUTICALS INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130165400-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | ALIOS BIOPHARMA, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130164261-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | ALIOS BIOPHARMA, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20120070415-A1 | AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS | ALIOS BIOPHARMA, INC. (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071434-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | ALIOS BIOPHARMA, INC. (US) | 2012-03-22 | — | — | US | disclosed |
| US-20100331397-A1 | 2-5A ANALOGS AND THEIR METHODS OF USE | ALIOS BIOPHARMA, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| EP-1139738-A1 | INSECTICIDAL SEED COATING | Syngenta Participations AG (CH) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035277-A1 | INSECTICIDAL SEED COATING | SYNGENTA PARTICIPATIONS AG (CH) | 2000-06-22 | — | — | WO | disclosed |
| US-4024049-A | Mono and di organophosphite esters as crude oil antifoulants | NALCO CHEMICAL COMPANY (US) | 1977-05-17 | — | — | US | disclosed |