Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840358 | 1.00 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2NR4A2RXRA | |
| SCHEMBL7843491 | 0.93 | EDNRA (0.51) | EDNRA | |
| SCHEMBL7843494 | 0.93 | EDNRA (0.51) | EDNRA | |
| SCHEMBL8151515 | 0.92 | EDNRA (0.58) | MEN1KMT2ASMN1; SMN2EDNRA | |
| SCHEMBL8151513 | 0.92 | EDNRA (0.58) | MEN1KMT2ASMN1; SMN2EDNRA | |
| SCHEMBL7840639 | 0.92 | EDNRA (0.50) | EDNRA | |
| SCHEMBL7840643 | 0.92 | EDNRA (0.50) | EDNRA | |
| SCHEMBL7844704 | 0.92 | EDNRA (0.52) | MEN1KMT2AEDNRA | |
| SCHEMBL7844707 | 0.92 | EDNRA (0.52) | MEN1KMT2AEDNRA | |
| SCHEMBL7843731 | 0.90 | EDNRA (0.58) | EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882030-B1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GMBH (DE) | 2001-09-12 | — | — | EP | disclosed |
| EP-0882030-A1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK PATENT GmbH (DE) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997030982-A1 | 2,1,3-BENZOTHIA(OXA)DIAZOLE DERIVATIVES HAVING AN ENDOTHELIN RECEPTOR ANTAGONISTIC EFFECT | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-08-28 | — | — | WO | disclosed |